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Introduction.

This paper was published in Cell Metabolism in 2024 by David A. Sinclair, Ph.D., author of LIFE SPAN – A World Without Aging, and colleagues. The paper examines the potential for delaying aging and extending healthy life expectancy against a backdrop of aging-related mechanisms and pathways identified through advances in aging research. Specifically, it provides a comprehensive summary of the current status of human clinical trials evaluating the effects of eight promising drugs and natural compounds on aging-related diseases. Aging is known to increase the risk of cancer, heart disease, and Alzheimer’s disease, and slowing aging may help prevent or treat these diseases.

Highlights.

• Many promising ingredients: Eight drugs and natural compounds, including metformin, NMN and other NAD precursors, and turmeric, have been evaluated in clinical trials against aging-related diseases.
• Drugs that delay aging and prevent disease: Agents that delay aging are expected to be effective in preventing or alleviating diabetes, cardiovascular disease, cancer, neurodegenerative diseases, and other diseases.
• Future treatments: ongoing clinical trials may pave the way for the development of new anti-aging drugs, and existing disease treatments may be repurposed to reduce the effects of aging.

Paper Information

Title of paper: Human trials exploring anti-aging medicines
Title of paper: Human trials exploring anti-aging medicines
Journal: Cell Metabolism
Abstract: This review summarizes clinical trials evaluating the effects of eight drugs and natural compounds, including metformin, NAD precursors, glucagon-like peptide-1 receptor agonists, TORC1 inhibitors, spermidine, senolytics, probiotics, and anti-inflammatory drugs, on aging-related diseases. The report summarizes clinical trials that evaluated the effects of eight drugs and natural compounds on aging-related diseases. It is hoped that these agents have the potential to slow or reverse the aging process, and the results of future clinical trials will help advance the development of new anti-aging drugs.

Tackling Aging: 8 Interventions and Human Clinical Trials

Previous studies have shown that certain genetic manipulations and caloric restriction can slow aging and extend lifespan in animal models, especially in rodents. However, it is difficult to apply these methods directly to humans, and there are safety and ethical issues involved. Therefore, approaches that use drugs and nutrients to intervene in the aging process have been attracting attention in recent years.

This paper details eight ingredients that are showing particular promise.

1. Metformin: Widely used as a treatment for diabetes, metformin is expected to slow aging through a variety of mechanisms, including activation of AMPK and inhibition of the mTOR pathway.
2. NMN, NR (NAD+ precursor): NAD+ is an essential coenzyme for intracellular energy metabolism and is known to decrease with aging. may increase NAD+ levels and improve various symptoms associated with aging.
3. Glucagon-like peptide-1 receptor agonist: GLP-1 receptor agonists have been used to treat diabetes, but recent studies have also reported neuroprotective and cardioprotective effects, and are expected to prevent aging-related diseases.
4. TORC1 inhibitor: Rapamycin inhibits mTORC1 and is known to slow aging by inhibiting cell growth and proliferation.
5. Spermidine: Spermidine, a polyamine, induces autophagy, thereby removing intracellular waste products and slowing down the aging process.
6. Aging cell eliminators: Aging cells are known to adversely affect surrounding cells by secreting inflammatory cytokines and other substances. Agents that remove senescent cells may inhibit inflammation and tissue dysfunction associated with aging.
7. Probiotics: Probiotics, which balance the intestinal microflora, may help prevent the deterioration of health associated with aging through modulation of immune function and suppression of inflammation.
8. Anti-inflammatory agents: Aging is known to be closely associated with chronic inflammation. Anti-inflammatory agents have the potential to reduce the risk of various aging-related diseases by reducing inflammation associated with aging.

These approaches may be an important means of reducing health problems associated with aging and extending healthy life expectancy.

For companies looking for safe, high-quality supplements containing NMN

At ZaaZ, an OEM of NMN supplements, we can handle the entire process from NMN formulation design, manufacturing, to quality control. We support the development of your original NMN supplements by utilizing the latest research findings in product development. We can handle even small lots, so please feel free to contact us for more information.

Author Profile.

Ichiro Aizawa
An expert on the supplement industry and an AI writer with knowledge of anti-aging and nutrition, Ichiro has received training from ZaaZ, an OEM of NMN supplements, and utilizes AI technology to provide high quality content. Her current mission is to help readers maintain and improve their health and wellness by communicating the latest nutrition and healthcare information in an easy-to-understand manner through on-demand media. I enjoy hiking and researching data science, and I enjoy blending nature and technology.