NMN and NR Dramatically Improve Fatty Liver in Non-Drinkers! Latest Research Reveals Mechanism of Liver Function Recovery

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A research team from China Medical University tested the effects of NMN and NR in a high-fat diet-induced NAFLD mouse model. The results showed that administration of NMN and NR suppressed body weight gain, improved blood glucose levels, regulated blood lipid levels, and reduced liver damage, oxidative stress, and lipid accumulation in NAFLD mice. In particular, NMN was found to be more effective in suppressing liver hypertrophy and improving liver damage compared to NR. On the other hand, NMN and NR were equally effective in reducing hepatic lipid accumulation and oxidative stress. These results suggest that NMN and NR have therapeutic effects to significantly improve liver dysfunction in NAFLD. Now let’s read the details in an easy-to-understand manner.

What is NAFLD, fatty liver that develops even in people who do not drink alcohol?

In recent years, there has been an increase in fatty liver disease that develops in people who do not drink alcohol. NAFLD is a disease in which fat accumulates in the liver against a background of lifestyle-related diseases such as obesity and diabetes. The number of patients with NAFLD is increasing worldwide, and there is an urgent need to establish effective treatment methods. In this context, a study has reported the results of a study that found the NAD supplements nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) to have potential as a therapeutic agent for NAFLD.

Highlights.

  • Treatment with NMN and NR inhibited body weight gain, improved blood glucose levels, and reduced liver injury, oxidative stress, and lipid accumulation in NAFLD mice
  • NMN and NR altered unsaturated fatty acid synthesis, arachidonic acid metabolism, and linoleic acid metabolic pathways in the NAFLD liver and favorably altered fatty acid composition
  • NMN and NR were shown to promote the breakdown of arachidonic acid and linoleic acid mainly via cytochrome P450 enzymes, suggesting that they may contribute to the reduction of lipid peroxidation.

Paper Information

Title of paper: Integrated transcriptome and metabolome study reveals the therapeutic effects of nicotinamide riboside and nicotinamide mononucleotide on nonalcoholic fatty liver disease
Title of Article: Integrated transcriptome and metabolome study reveals the therapeutic effects of nicotinamide riboside and nicotinamide mononucleotide on nonalcoholic fatty liver disease
Journal: Biomedicine & Pharmacotherapy

NMN and NR Significantly Improve Liver Function in NAFLD Model Mice

Using state-of-the-art analytical methods, a research team from China Medical University has conducted a detailed study of the effects of NMN and NR on NAFLD liver metabolism. The analysis revealed that administration of NMN and NR caused changes in the unsaturated fatty acid synthesis pathway, arachidonic acid metabolism pathway, and linoleic acid metabolism pathway in the NAFLD liver. Specifically, a decrease in saturated fatty acids and an increase in polyunsaturated fatty acids were observed. In addition, NMN and NR were shown to promote the breakdown of arachidonic acid and linoleic acid, mainly via cytochrome P450 enzymes. These findings suggest that NMN and NR may contribute to the improvement of NAFLD pathogenesis by altering the fatty acid composition of the NAFLD liver and reducing lipid peroxidation.

Potential for NAFLD Treatment with NAD Supplementation

This study has demonstrated that NMN and NR significantly improve liver dysfunction and abnormal lipid metabolism in NAFLD model mice. NMN and NR have great potential as new therapeutic targets for NAFLD. In the future, their safety and efficacy should be carefully verified through human clinical studies. The findings of this study are expected to provide an important foundation for the development of NAFLD therapies, and further progress toward the establishment of new therapeutic strategies based on metabolic control by NMN and NR is encouraged.

For companies looking for safe, high-quality supplements containing NMN

At ZaaZ, an OEM of NMN supplements, we can handle the entire process from NMN formulation design, manufacturing, to quality control. We support the development of your original NMN supplements by utilizing the latest research findings in product development. We can handle even small-lot production, so please feel free to contact us for more information.

Author Profile

Ichiro Aizawa
An expert on the supplement industry and an AI writer with knowledge of anti-aging and nutrition, Ichiro has received training from ZaaZ, an OEM of NMN supplements, and utilizes AI technology to provide high quality content. Her current mission is to help readers maintain and improve their health and wellness by communicating the latest nutrition and healthcare information in an easy-to-understand manner through on-demand media. She enjoys hiking and researching data science, and enjoys blending nature and technology.

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