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The article “Mitochondrial sirtuins: Energy dynamics and cancer metabolism” by Hojun Lee and Haejin Yoon from Ulsan National University of Science and Technology, Korea, published in 2024, is an important discovery to elucidate how mitochondria regulate cancer cell metabolism. Mitochondria are the energy centers of the cell. Mitochondria are the primary site for the production of ATP, the energy currency of cells, and their dysfunction is implicated in various diseases, including cancer. In this paper, a group of enzymes called sirtuins, especially SIRT3, SIRT4, and SIRT5, which are found in mitochondria, were identified to play an important role in regulating cancer cell metabolism. These sirtuin genes have the potential to intervene in the abnormal metabolic pathways of cancer cells and control their growth and survival. In particular, the activation of SIRT3, SIRT4, and SIRT5 is a new target for cancer therapy. In this article, based on Lee and Yoon’s paper, we will discuss in detail the link between mitochondrial sirtuins and cancer metabolism and the prospects for future therapeutic strategies that their discovery may bring.

Highlights

• Sirtuins localized in mitochondria play an important role in cancer cell metabolism and are expected to be a new therapeutic target.
• NMN is a precursor of NAD+, which is essential for sirtuin activity, and increasing the supply of NMN may enhance sirtuin activity.
• The use of state-of-the-art technologies such as proteomics and metabolomics will allow us to better understand the link between mitochondria, sirtuins, and cancer metabolism.

Paper Information

Title of paper: Mitochondrial sirtuins: Energy dynamics and cancer metabolism
Title of paper: Mitochondrial sirtuins: Energy dynamics and cancer metabolism
Publication name: Molecules and Cells Minireview
Abstract: Mitochondria play a central role in cellular energy metabolism. This paper describes how the mitochondrial enzyme sirtuin regulates the metabolism of cancer cells. Cancer cells are known to have energy-producing pathways that differ from those of normal cells, and sirtuins have the potential to intervene in these abnormal metabolic pathways and control cancer cell growth and survival.

Article Abstract

Cancer cells employ energy-producing pathways that differ from those of normal cells in order to maintain their vigorous proliferation. This phenomenon, known as the Warburg effect after its discoverer, has become an important target in the field of cancer therapy, and Lee and Yoon’s paper suggests that mitochondria-localized sirtuins, particularly SIRT3, SIRT4, and SIRT5, are deeply involved in the metabolic regulation of cancer cells, including the Warburg effect. SIRT3 functions as a major mitochondrial deacetylase and regulates various processes involved in energy metabolism, including fatty acid oxidation, amino acid metabolism, and the TCA circuit; SIRT4 is required for cancer cell growth It has been suggested that SIRT5 may inhibit cancer cell growth by inhibiting glutamine metabolism; SIRT5 is thought to affect cancer cell metabolism and survival by regulating metabolic pathways through protein desuccinylation and deacetylation. Interestingly, these sirtuins require a cofactor, NAD+, for their activity; NAD+ plays an important role in cellular redox reactions and energy metabolism, and maintaining appropriate intracellular levels of NAD+ is critical to sirtuin function.

Discussion by an OEM company of NMN supplements

This paper shows that the activation of sirtuins, which are involved in mitochondrial activation, normalizes abnormal metabolic pathways in cancer cells and inhibits cancer cell growth and survival.NMN has been suggested to improve mitochondrial function and inhibit cancer cell growth NMN has been shown to improve mitochondrial function and inhibit cancer cell proliferation. On the other hand, mRNA vaccines can efficiently induce cellular immunity to attack cancer cells by inducing the expression of cancer antigen proteins in the body. Therefore, we felt that the combination of NMN and mRNA could produce the following cancer vaccines.

• NMN improves mitochondrial function of cancer cells and suppresses their proliferation.
• At the same time, mRNA vaccine induces cancer antigen-specific cellular immunity and attacks cancer cells.
• These two effects may effectively suppress the development and progression of cancer.

However, research on cancer vaccines that actually combine NMN and mRNA has not yet been fully conducted. It is hoped that the following studies will lead to the development of new cancer vaccines using NMN and mRNA.

• Studies to further elucidate the cancer-inhibitory effects of NMN in detail.
• Studies to enhance the safety and efficacy of mRNA vaccines
• Examination of optimal combination and administration methods of NMN and mRNA

The potential of NMN and mRNA in cancer therapy is very interesting, but much more research is still needed before clinical application. We hope that steady progress in basic research will lead to the development of innovative cancer therapies in the future.

For companies looking for safe, high-quality supplements containing NMN

At ZaaZ, an OEM of NMN supplements, we can handle the entire process from NMN formulation design, manufacturing, to quality control. We support the development of your original NMN supplements by utilizing the latest research findings in product development. We can handle even small-lot production, so please feel free to contact us for more information.

Author Profile

Ichiro Aizawa
An expert on the supplement industry and an AI writer with knowledge of anti-aging and nutrition, Ichiro has received training from ZaaZ, an OEM of NMN supplements, and utilizes AI technology to provide high quality content. Her current mission is to help readers maintain and improve their health and wellness by communicating the latest nutrition and healthcare information in an easy-to-understand manner through on-demand media. She enjoys hiking and researching data science, and enjoys blending nature and technology.