Production process of NMN raw materials by fermentation method and research trend of NMN

Nicotinamide mononucleotide (NMN) has attracted much attention in the field of anti-aging, but how advanced is the research on its production method and latest health benefits? This article describes how NMN raw materials are produced by fermentation methods and the potential of NMN for diabetes, middle age weight gain, and Alzheimer’s disease, based on the latest research trends.

1. about NMN’s production method by fermentation

This section focuses on the basic principles of the production method by the fermentation method, which we also employ, and the process of production.

NMN production by the fermentation method

The fermentation method is a method to produce NMN by cultivating NMN through biological processes using specific microorganisms, mainly yeast and bacteria. Since this method utilizes the metabolic activities of microorganisms to produce NMN, it is an environmentally friendly manufacturing method compared to the chemical synthesis method. The fermentation method is able to purify NMN with high purity and stable quality because there is no risk of chemical residues in the manufacturing process.

Since the manufacturing process of the fermentation method varies from manufacturer to manufacturer, the following is a general NMN raw material manufacturing process. In the first step, ribose, a type of sugar, is mixed with nicotinic acid amide. This mixture is then fermented in a fermentation kettle using yeast and certain enzymes to purify the NMN. The mixture is then filtered using a centrifuge or other means to separate impurities and increase the purity of the NMN. Filtering is usually performed multiple times to thoroughly remove impurities and increase the purity of NMN.

After the purity meets certain standards, crystallization and drying processes are performed. This process reduces the water content of NMN and improves product stability. Then microbiological and other safety tests are conducted, and only those NMN that meet strict criteria are used in the granulation process to adjust the particle size of the NMN. This makes NMN a suitable raw material for the production of supplements, which are then delivered to the supplement manufacturing plant.

2. comparison of chemical synthesis and fermentation methods

The chemical synthesis method is suitable for mass production and tends to be less expensive to produce than the fermentation method. However, the chemical synthesis method has an aspect of concern about residual organic solvents used during purification. We exchange information on NMN trends with several NMN raw material manufacturers around the world on an irregular basis, and about 80% of the manufacturers are of the opinion that the chemical synthesis method should be carefully considered from a safety standpoint.

Some inexpensive NMN supplements on the market do not specify the manufacturing process. Considering the unit cost of raw materials, it is possible that NMN supplements that do not clearly state the manufacturing process may be using chemically synthesized NMN. For consumers, transparency of the manufacturing process is required, so it is important to select products that clearly state the manufacturing process.

3. latest research trends on NMN

NMN has become an ingredient that has been attracting attention in the field of anti-aging care in recent years. However, its benefits are not limited to anti-aging. According to the latest research, NMN is expected to have effects on diabetes, middle-aged weight gain, and Alzheimer’s disease, offering new hope for people with these problems. This chapter describes the potential of NMN for these diseases based on the latest research trends.

Effects of NMN on Diabetes

Recent studies have shown that NMN (nicotinamide monucleotide) may improve muscle insulin sensitivity in women at risk for diabetes*1 Specifically, administration of NMN has been suggested to enhance insulin effectiveness and improve glucose metabolism. This may be beneficial in the prevention and management of diabetes. Furthermore, NMN is thought to be able to assist in reducing insulin resistance and improving glycemic control.

Effects of NMN on Middle-Aged Weight Gain

A recent study showed that when mice were fed NMN from 5 months of age for one year, their metabolism was maintained and they did not gain weight at the age of 17 months, which is equivalent to the age of 60s in humans, Anti-aging effects have been observed in skeletal muscle, liver, and fat. In particular, mice that took NMN showed higher insulin sensitivity to lower blood glucose levels than the control group that did not take NMN, and anti-aging effects were also confirmed, such as the preservation of retinal function, bone density, and immune cells in the eyes, which decline with aging. These results suggest that NMN may not only prevent middle-aged weight gain, but also delay the aging process of the entire body. *2

Effect of NMN on Alzheimer’s Disease

Alzheimer’s disease is a neurodegenerative disorder for which there are currently limited treatment options. However, some studies suggest that NMN may slow the progression of Alzheimer’s disease by helping to protect and regenerate neurons*3 Specifically, NMN has been shown to reduce neuronal damage in mouse models of Alzheimer’s disease. Furthermore, NMN may contribute to reduced neuroinflammation and improved cognitive function.

4. Conclusion

NMN (nicotinamide mononucleotide) is known as an ingredient of interest in the field of anti-aging, but its potential does not stop there. According to the latest research, it also has potential effects on diabetes, middle-aged weight gain, and even Alzheimer’s disease. In this article, we have described the production method of NMN and the latest research trends related to it.

NMN Production Method (Fermentation Method)
There are several methods to produce NMN, but this article focuses on the fermentation method in particular. The fermentation method utilizes specific microorganisms, mainly yeast and bacteria, to produce NMN through biological processes. This method is more environmentally friendly than the chemical synthesis method and has no risk of chemical residues in the production process. It is also possible to provide NMN of high purity and stable quality. As we place the highest priority on consumer safety and providing high quality NMN, we use this fermentation method to manufacture NMN supplements on an OEM basis.

Comparison of chemical synthesis method and fermentation method
There are two main methods of NMN production: chemical synthesis and fermentation. The chemical synthesis method is suitable for mass production and can keep production costs low. However, there are concerns about residual organic solvents. On the other hand, the fermentation method is important for consumers who require transparency in the manufacturing process and is an excellent choice in terms of safety.

Current Research Trends in NMN
While NMN is popular in the field of anti-aging, the latest research suggests that it may also have benefits for diabetes, middle-aged weight gain, and Alzheimer’s disease. For diabetes, NMN has been shown to improve muscle insulin sensitivity1; for weight gain, NMN has been shown to maintain the body’s metabolism and have anti-aging effects2; and for Alzheimer’s disease, NMN has been shown to help protect and regenerate nerve cells and improve disease progression. 2 Furthermore, for Alzheimer’s disease, it has been suggested that NMN may support the protection and regeneration of nerve cells and slow down the progression of the disease*3.

The quest for NMN continues and has the potential to offer new hope for people with these diseases. And understanding how NMN is produced and the latest research trends related to it will be key to further expanding the potential of this ingredient.

Source:.
*1 Science. 2021;372(6547):1224-1229 Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
https://www.science.org/doi/10.1126/science.abe9985

*2 Shinichiro Imai, Professor at the University of Washington, talks about “NMN, the truth about its anti-aging effects”.
https://project.nikkeibp.co.jp/behealth/atcl/feature/00043/090800005/

*3 Yao Z, Yang W, Gao Z, Jia P. Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease. Neurosci Lett. 2017;647:133-140. doi:. 10.1016/j.neulet.2017.03.027.

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